That is what we are watching now. Silicon Valley Bank, the first financial institution to capsize in the latest crisis, had moored itself to long-term Treasury bonds bought when interest rates were at record lows. These federal IOUs are considered safe assets, but they are not bulletproof.
When interest rates rise, fixed-rate paper offering low yields becomes deeply unattractive. Why buy or hold a bond paying only a fraction of what is available in the higher-interest-rate market?